Targeting Prolyl 3-hydroxylase 1 inhibits pancreatic cancer progression and macrophage immunity - PubMed
6 hours ago
- #PLK1
- #pancreatic cancer
- #P3H1
- Prolyl 3-hydroxylase 1 (P3H1) plays a pivotal role in pancreatic ductal adenocarcinoma (PDAC) progression.
- P3H1 regulates Polo-like kinase 1 (PLK1) and PLK1-mediated β-catenin signaling, influencing tumor cell proliferation and macrophage infiltration.
- Restoration of P3H1 or PLK1 in P3H1-deficient cells reverses β-catenin signaling defects and promotes tumor growth.
- Pharmacological inhibition of PLK1 enhances chemotherapeutic efficacy against PDAC, reducing tumor burden in mice.
- The study suggests P3H1 as a promising therapeutic target for PDAC treatment.