Shared splicing dysregulation in heart failure associated with dilated and ischemic cardiomyopathy and spatial specificity across cardiac regions - PubMed
8 hours ago
- #Heart Failure
- #Cardiomyopathy
- #Alternative Splicing
- Alternative splicing is crucial in cardiac function and becomes dysregulated in heart failure.
- Widespread splicing alterations are shared between dilated (DCM) and ischemic cardiomyopathy (ICM) patients.
- Spatial analysis shows some splicing changes across all heart chambers in DCM, while ICM changes may be restricted to the left ventricle.
- The RNA-binding protein QKI is implicated as a potential regulator of splicing dysregulation in heart failure.