COL3A1high cancer-associated fibroblasts orchestrate metabolic and immune microenvironments to confer chemoresistance in breast cancer - PubMed
4 hours ago
- #chemoresistance
- #breast cancer
- #cancer-associated fibroblasts
- COL3A1high cancer-associated fibroblasts (CAFs) drive chemoresistance in breast cancer.
- These CAFs undergo lipid metabolic reprogramming, secreting oleic acid via SCD.
- Oleic acid binds to ENO1 on tumor cells, activating the PI3K/Akt pathway and inhibiting apoptosis.
- COL3A1high CAFs create an immunosuppressive niche by recruiting regulatory T cells and impairing CD8+ T cells.
- COL3A1high CAF abundance correlates with poor clinical response, suggesting their role as predictive biomarkers and therapeutic targets.