Gene regulatory landscape dissected by single-cell four-omics sequencing - PubMed
5 hours ago
- #Epigenomics
- #Gene regulation
- #Single-cell sequencing
- Single-cell four-omics method CHARM profiles genome conformation, histone modifications, chromatin accessibility, and gene expression in same cell.
- Applied in mouse embryonic stem cells and cortical tissues, revealing cell-cycle dynamics and spatial clustering in nuclear architecture.
- Machine learning identified accurate enhancer-promoter linkages specific to cell types and subtypes.