TANK-binding kinase 1 protects against MASH progression via mitochondrial quality control - PubMed
5 hours ago
- #MASH
- #mitochondrial quality control
- #TBK1
- TBK1 is identified as a key regulator of hepatic mitophagy and lysosomal activity.
- TBK1 deficiency leads to accumulation of dysfunctional mitochondria due to impaired mitophagy and lysosomal degradation.
- TBK1 phosphorylates p62 at Ser403 and modulates mTOR signaling to maintain lysosomal function.
- TBK1 kinase activity is significantly reduced in both human MASH samples and murine models.
- Restoring TBK1 expression via AAV8 in MASH mice improves mitophagy, reduces mitochondrial burden, and alleviates liver fibrosis.
- TBK1 acts as a critical protector of mitochondrial and lysosomal homeostasis in MASH.