Nanomaterials for Alzheimer's disease: emerging strategies in diagnosis and therapy - PubMed

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder with significant challenges in early diagnosis and treatment.
Nanotechnology-based strategies are emerging as promising solutions for AD due to their ability to detect biomarkers and cross biological barriers.
Recent advances include nanomaterials for sensitive detection of AD-related biomarkers through sensing and imaging technologies.
Nanomaterials also offer therapeutic benefits, such as improving drug solubility, enhancing blood-brain barrier penetration, and enabling controlled drug release.
Targeted therapies focus on neurons, microglia, astrocytes, Aβ, Tau, mitochondria, and iron, with multifunctional nanostructures enabling synergistic multi-target approaches.
Integrated strategies combine antioxidant, anti-inflammatory, anti-aggregative, and neuroprotective mechanisms for personalized AD management.

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