Local delivery of OSK factors enables partial cellular reprogramming to mitigate osteoarthritis and cartilage fibrosis - PubMed
5 days ago
- #cellular reprogramming
- #cartilage regeneration
- #osteoarthritis
- Local delivery of OSK factors (Oct4, Sox2, Klf4) via AAV vector enables partial cellular reprogramming to mitigate osteoarthritis (OA) and cartilage fibrosis.
- AAV-OSK preserves chondrocyte vitality, prevents osteogenic gene upregulation, and reduces chondrocyte senescence in inflammatory conditions.
- In OA murine models, AAV-OSK improves cartilage integrity, reduces subchondral bone thickening, and promotes hyalinization of fibrocartilage.
- OSK expression modulates epigenetic alterations, particularly through Tet methylcytosine dioxygenase 2, aiding cartilage regeneration and OA intervention.
- The study highlights the therapeutic potential of OSK-driven partial reprogramming for comprehensive OA treatment without increasing stemness-associated genes.