Serial Myocardial Fibrosis Assessments Predict Outcomes in Patients With Hypertrophic Cardiomyopathy - PubMed
4 days ago
- #myocardial fibrosis
- #cardiac MRI
- #hypertrophic cardiomyopathy
- Serial myocardial fibrosis assessments via cardiac magnetic resonance (CMR) can predict outcomes in hypertrophic cardiomyopathy (HCM) patients.
- The study analyzed 313 HCM patients with two CMR studies, tracking late gadolinium enhancement (LGE) progression over a median interval of 4.2 years.
- LGE mass increased from a median of 2.9 g to 8.3 g, with progression rates (>1.50 g/year) linked to higher risk of adverse outcomes.
- ΔLGE mass/year >1.50 g/year independently predicted primary endpoints (HR: 2.22) and improved risk stratification (C statistic: 0.81 to 0.84).
- External validation confirmed the prognostic value of ΔLGE mass/year in multicenter datasets.
- Findings suggest serial CMR assessments of fibrosis may enhance clinical decision-making in HCM management.