Real life management of intraductal papillary mucinous neoplasms of the pancreas: Final data from the prospective Italian pancreatic cysts (PANCY) registry - PubMed
5 hours ago
- #Pancreatic Cancer
- #IPMN
- #Oncology
- Study focused on identifying factors associated with relevant changes in low-risk Intraductal Papillary Mucinous Neoplasms (IPMNs) under surveillance.
- Analysis included 647 IPMN patients from the PANCY registry, with 60% being branch duct (BD) type.
- 8.8% of patients underwent immediate surgery, while 91.2% were placed under active surveillance.
- Malignancy rates were 2.7% for BD-IPMNs and 12.5% for mixed-type IPMNs under surveillance.
- Smoking and cyst size >15 mm at diagnosis were independent risk factors for relevant changes.
- Cyst size ≤15 mm and age >65 were protective factors, especially in non-smokers.
- Conclusion: BD-IPMN progression risk is low for small lesions (<15 mm) in non-smokers over 65 years.
- Current surgery and follow-up criteria are imperfect, leading to potential overuse of resources.