Unveiling of Placental-Fetal Heart Interplay: A Novel Etiologic and Therapeutic Insight-A Narrative Review - PubMed
6 hours ago
- #Congenital Heart Disease
- #Fetal Development
- #Placental Insufficiency
- Congenital heart disease (CHD) is the most common fetal anomaly worldwide, with most etiologies attributed to epigenetic and environmental factors.
- Placental malformation is an emerging overlooked cause of CHD, with placental insufficiency potentially leading to cardiac remodeling.
- There is a two-way communication between placental and fetal heart diseases, with shared developmental regulatory pathways.
- Fetal vascular malperfusion and genetic defects may contribute to both placental and fetal heart disorders.
- Disturbed embryonic blood flow, syncytialization deformities, and umbilical cord disorders can lead to cardiac underdevelopment.
- Genetic, epigenetic, hormonal, and regulatory factors (e.g., NOTCH signaling, SUMO-modulated stress responses, autophagy-related genes) affect both placental and fetal heart development.
- The study highlights the interplay between the placenta and fetal heart, offering new insights into CHD and placental insufficiency etiologies.