Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis - PubMed
14 hours ago
- #GnRH
- #microglia
- #reproductive health
- Microglia Rank signaling plays a crucial role in regulating GnRH neuronal function and the hypothalamic-pituitary-gonadal (HPG) axis.
- Depletion of Rank in microglia leads to hypogonadotropic hypogonadism (HH) by altering GnRH neuron function.
- Rare gene variants of RANK were identified in patients with HH, linking Rank signaling to reproductive disorders.
- Transcriptional profiling showed that Rank loss causes defective microglia activation and morphological changes in the median eminence.
- Microglia regulate GnRH neuronal function through Rank signaling, impacting reproductive maturation and fertility.