Complete biosynthesis of psychedelic tryptamines from three kingdoms in plants - PubMed
21 hours ago
- #psychedelic biosynthesis
- #metabolic engineering
- #tryptamines
- Complete biosynthesis of N,N-dimethyltryptamine (DMT) elucidated in hallucinogenic plants.
- Reconstructed pathways in a plant assay for five psychedelics: psilocin, psilocybin, DMT, bufotenin, and 5-methoxy-DMT.
- Engineered halogenated analogs with potential therapeutic use for psychiatric conditions.
- Enhanced production efficiency via cross-kingdom enzyme blending and metabolic engineering.
- Established a platform for concurrent biosynthesis and diversification of psychoactive tryptamines in plants.