An inflammasome-driven differentiation program in intestinal stem cells protects against Salmonella infection - PubMed
3 hours ago
- #Inflammasome
- #Salmonella infection
- #Intestinal stem cells
- Intestinal stem cells (ISCs) detect intracellular Salmonella via an inflammasome mechanism.
- Invaded ISCs rapidly differentiate into antimicrobial Paneth cells through ASC-mediated inflammasome signaling.
- This stem cell-driven fate switch enhances epithelial antimicrobial capacity and restricts pathogen persistence.
- The response is Salmonella-specific and conserved in human intestinal organoids.
- ISCs act as active sensors of bacterial invasion, initiating epithelial remodeling through inflammasome signaling.