A Multi-Organ Atlas Links Gut Microbial Metabolites to Systemic Redox Changes in Aging Mice - PubMed
3 days ago
- #redox balance
- #aging
- #gut microbiota
- A multi-organ, multi-omics atlas was created to study gut microbial metabolites and systemic redox changes in aging mice.
- Aging was found to deplete protective circulating metabolites like lysophosphatidylcholines (LPCs) and increase pro-oxidative microbial catabolites such as TMAO and IAA.
- This microbial-metabolic shift disrupted lipid transport and redox balance, leading to organ-specific vulnerabilities in the liver, lungs, and cortex.
- A meta-analysis of 40 studies confirmed that microbial remodeling is linked to aging phenotypes, including intestinal barrier integrity, inflammation, and oxidative stress.
- The findings suggest gut-derived metabolic reprogramming as a modifiable driver of systemic aging, offering potential therapeutic targets.