Restoration of circadian rhythm as novel targets against sarcopenia - PubMed
4 hours ago
- #aging
- #circadian-rhythm
- #sarcopenia
- Sarcopenia involves age-related decline in muscle mass, strength, and function, leading to high healthcare costs and risks like falls and mortality.
- There are currently no FDA-approved drugs for sarcopenia, partly due to incomplete understanding of its mechanisms.
- Two key factors in sarcopenia development are disrupted circadian rhythms affecting protein remodeling, insulin resistance, and mitochondrial function, and systemic chronic low-grade inflammation.
- This review focuses on circadian rhythm regulators' roles in muscle deterioration and their interactions with inflammation.
- Strategies to restore circadian synchrony and resolve inflammation are proposed as novel therapeutic approaches against sarcopenia.