Oxaloacetate Restores HIF-1α-Mediated Mitochondrial Homeostasis to Counter Tubulointerstitial Injury in Diabetic Kidney Disease - PubMed
6 hours ago
- #Oxaloacetate
- #Mitochondrial Homeostasis
- #Diabetic Kidney Disease
- Oxaloacetate (OAA) supplementation mitigates tubulointerstitial injury in diabetic kidney disease (DKD).
- OAA restores mitochondrial homeostasis by inhibiting prolyl hydroxylase domain 2 (PHD2), stabilizing hypoxia-inducible factor-1α (HIF-1α).
- Metabolomic analysis revealed decreased OAA levels in injured renal tubular cells in DKD.
- Pharmacological inhibition of HIF-1α negates the protective effects of OAA, confirming the PHD2/HIF-1α axis's role.
- OAA treatment reduces tubular cell damage, fibrosis, and macrophage infiltration in DKD models.