Dapagliflozin-induced integrated improvements in left ventricular diastole, endothelial function, and arterial load: a randomized clinical trial - PubMed
6 hours ago
- #Dapagliflozin
- #Diastolic Function
- #Endothelial Function
- Dapagliflozin improved left ventricular diastolic function compared to glibenclamide in patients with type 2 diabetes, as shown by a reduction in E/e' ratio.
- Endothelial function improved with dapagliflozin, indicated by increased nitric oxide bioavailability and flow-mediated dilation.
- Changes in diastolic function correlated with reductions in arterial impedance and improvements in endothelial markers, suggesting a vascular-myocardial pathway.
- The study found no significant correlations between diastolic function changes and systemic vascular resistance or ventricle-arterial coupling.
- Dapagliflozin was associated with a lower likelihood of worsening diastolic function, highlighting potential cardioprotective effects in at-risk populations.