The NPC1/USP7/p53 axis regulates cholesterol and promotes the proliferation of hepatocellular carcinoma - PubMed
6 hours ago
- #p53 regulation
- #cholesterol metabolism
- #NPC1
- NPC1 is overexpressed in hepatocellular carcinoma (HCC) and associated with poor prognosis.
- NPC1 silencing inhibits HCC cell proliferation both in vitro and in vivo.
- NPC1 interacts with USP7, disrupting its binding to p53, leading to p53 destabilization via enhanced ubiquitination and degradation.
- NPC1 modulates cholesterol synthesis and distribution through the p53-SREBP2 axis.
- Pharmacological activation of p53 can reverse cholesterol changes induced by NPC1, highlighting NPC1 as a potential therapeutic target in HCC.