NSUN2 promoted tumor growth and metastatic via m5C-regulation of YAP through ALYREF/YBX1 axis in NSCLC - PubMed
4 days ago
- #NSCLC
- #YAP signaling
- #RNA methylation
- NSUN2 promotes tumor growth and metastasis in NSCLC via m5C-regulation of YAP through the ALYREF/YBX1 axis.
- NSUN2 increases m5C modification of YAP mRNA, enhancing its stability and translation via ALYREF and YBX1.
- A positive feedback loop exists where YAP-TEAD2 complex transcriptionally activates NSUN2, further promoting tumor progression.
- Inhibition of m5C modification shows potential as a therapeutic strategy for NSCLC.
- The study highlights the role of RNA modifications (m5C) in cancer progression and therapy resistance.