UBA1-CDK16: A female-specific chimeric RNA emerging through evolution and involved in immune regulation - PubMed
4 hours ago
- #Myeloid Regulation
- #Sex-specific Immunity
- #Chimeric RNA
- A female-specific chimeric RNA, UBA1-CDK16, forms via cis-splicing between two X-linked genes, UBA1 and CDK16, in humans.
- It arises from a female-specific chromatin loop at the gene junction and became female-specific through at least two independent evolutionary paths.
- UBA1-CDK16 is enriched in myeloid lineage cells and may regulate myeloid cell development and immune function.
- In female COVID-19 patients, abnormal expression of UBA1-CDK16 correlates with changes in neutrophil counts, suggesting a role in disease progression.