Identifying genetic contributions of 6q21 loci and PPAR pathway to antipsychotic-induced metabolic syndrome: a Sex-Stratified Multi-Omics study - PubMed
5 hours ago
- #genetics
- #antipsychotics
- #metabolic syndrome
- Study identifies genetic variants on chromosome 6q21 (rs73762168) linked to antipsychotic-induced metabolic syndrome (APs-induced MetS) in male patients.
- Genes NR2E1, SNX3, and AFG1L/LACE1 are associated with APs-induced MetS, validated in an independent cohort.
- PPAR signaling pathway, involved in oxidative stress and fatty acid metabolism, is highlighted as a key contributor to APs-induced MetS.
- Baseline SNX3 protein levels correlate with weight gain and increased waist circumference after antipsychotic treatment.
- Multi-omics prediction combining genetic and proteomic markers improves prediction of metabolic side effects (R²=0.18).
- Findings suggest potential targets for early risk prediction and personalized treatment strategies, particularly in males.