Sinusoidal cell-derived biomarker scores predict diagnosis and prognosis in chronic liver disease - PubMed
5 hours ago
- #biomarkers
- #sinusoidal cells
- #chronic liver disease
- Sinusoidal cell-derived biomarker scores predict diagnosis and prognosis in chronic liver disease (CLD).
- Single-cell RNA sequencing identified signatures for liver sinusoidal endothelial cell capillarization, hepatic stellate cell activation, and macrophage polarization.
- Three sinusoidal scores (endothelial, mesenchymal, macrophage) were developed and validated in multiple cohorts (n=1008).
- Scores correlated with clinical endpoints like decompensation, portal hypertension, and liver function impairment.
- Baseline scores predicted fibrosis progression, regression, and clinical outcomes during follow-up.
- Scores can be measured from existing biopsy material, enabling global feasibility.
- Potential clinical applications include patient stratification, monitoring, and therapeutic guidance.