The association between systemic inflammation markers and breast cancer - PubMed
4 days ago
- #inflammation-markers
- #biomarkers
- #breast-cancer
- Breast cancer is a common malignant tumor in women globally, with inflammation playing a key role in its development.
- The study analyzed 19,734 participants from NHANES to assess the link between six systemic inflammatory markers and breast cancer prevalence.
- Platelet-to-lymphocyte ratio (PLR) showed a significant positive correlation with breast cancer (OR = 1.35; 95% CI:1.09, 1.67) and demonstrated good predictive performance.
- Other markers like MLR, NLR, SII, SIRI, and AISI were also positively associated with breast cancer prevalence.
- Subgroup analysis found no significant differences in the association between PLR and breast cancer across population groups.
- ROC curve analysis indicated PLR (AUC = 0.59) outperformed other markers in predicting breast cancer.
- Systemic inflammatory markers, especially PLR, show potential as biomarkers for early breast cancer detection.
- Individuals with elevated inflammation markers should monitor for potential breast cancer risks.