Functional targeting of PTTG1 in pericytes restores vascular integrity in diabetic retina - PubMed
3 days ago
- #Diabetic Retinopathy
- #Pericyte Dysfunction
- #PTTG1 Targeting
- A single-cell RNA sequencing study identified a pericyte subpopulation expressing high levels of PTTG1 in diabetic retinas.
- CRISPR-Cas9 or siRNA-mediated silencing of PTTG1 restored pericyte stability and barrier function under high-glucose conditions.
- In vivo silencing of Pttg1 improved retinal vascular integrity and reduced dysfunction in diabetic mice.
- PTTG1 silencing reprogrammed metabolism by modulating glycolysis and reducing oxidative stress, as shown by integrated transcriptomic and metabolomic analysis.
- A therapeutic approach using spherical nucleic acid-based siPttg1 nanocarriers (sTDN-siPttg1) significantly ameliorated retinal vascular dysfunction in a diabetic retinopathy model.