Anti-interferon-γ autoantibody-mediated immunodeficiency with disseminated Mycobacterium massiliense and secondary Sweet syndrome: A case report - PubMed
4 hours ago
- #Sweet Syndrome
- #Autoantibody
- #Mycobacterial Infection
- A 70-year-old Asian female with a one-year progressive neck mass, recurrent fever for six months, and painful skin lesions was diagnosed with disseminated Mycobacterium massiliense infection, Sweet syndrome, and anti-interferon-γ autoantibody-mediated immunodeficiency (AIGA-AOID).
- The patient was treated with combined therapy including rituximab, corticosteroids, and a 12-month oral antimycobacterial regimen, leading to significant clinical improvement within two weeks and regression of lymphadenopathy and lung consolidation at three months.
- Sweet syndrome can be a presenting sign of disseminated non-tuberculous mycobacterial disease, highlighting the importance of investigating for AIGA-mediated immunodeficiency in immunocompetent-appearing adults, especially in endemic regions.