Diverse Food Allergen IgG Reactivities Are Associated With Food Allergies in the Boston Birth Cohort - PubMed
7 days ago
- #food allergies
- #immune regulation
- #IgG reactivity
- Study investigates IgG antibodies' role in food allergies using the Boston Birth Cohort.
- 458 children studied: 80 with food allergies, 151 sensitized, 227 non-allergic controls.
- PhIP-Seq used to profile IgG reactivity against allergens and viruses in cord and childhood blood.
- Food-allergic children showed higher IgG reactivity diversity to allergen peptides in early childhood.
- Peanut-allergic children had higher IgG reactivity to 24 peanut peptides; egg-allergic to 17 egg peptides.
- Milk-allergic children had lower IgG reactivities to milk and enteroviral peptides compared to controls.
- Findings suggest IgG profiling offers insights into immune regulation and childhood allergies.