Pharmacological regulation of adult brain neuroplasticity: Synergistic roles of neuropeptide signaling, psychedelics, and synaptic modulators - PubMed
6 hours ago
- #Psychedelics
- #Synaptic Modulators
- #Neuroplasticity
- Neuroplasticity allows the brain to modify synaptic connections and reorganize neural circuits, supporting cognitive function and emotional regulation.
- Pharmacological interventions targeting synaptic modulators (NMDA, AMPA, GABA receptors), neuropeptide systems (BDNF, oxytocin, vasopressin), and psychedelics (psilocybin, LSD, ketamine) can enhance neuroplasticity.
- Key findings include rapid-acting antidepressant effects of NMDA antagonists and structural reorganization induced by psychedelics via 5-HT2A receptor activation.
- Neuropeptides play neurorestorative roles in synaptic and network adaptation.
- Safety, ethical considerations, and risks of maladaptive plasticity are critical, emphasizing controlled therapeutic environments and proper dosing.
- Emerging non-hallucinogenic neuroplastogens and combinatorial approaches offer safer ways to fine-tune neuroplasticity.
- Neuroplasticity-targeting pharmacology holds promise for treating neuropsychiatric and neurodegenerative disorders in adults.