A Hormone Cell Atlas maps the human endocrine system at cellular resolution - PubMed
2 hours ago
- #single-cell analysis
- #hormone mapping
- #endocrine system
- A Hormone Cell Atlas maps the human endocrine system at the cellular level, analyzing 379 hormone and receptor genes.
- It uses a transcriptomic dataset of 14 million single cells and nuclei across 47 human tissues to map hormone-producing and receiving cell types.
- The atlas predicts non-classical hormone expression sites, such as secretin in plasmacytoid dendritic cells, and identifies endocrine feedback loops.
- It reveals dynamic endocrine programs in adipocytes across depots, subtypes, and during differentiation.
- The atlas serves as a framework for understanding hormonal impacts on health and disease, accessible at hormonecellatlas.org.uk.