Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial - PubMed
2 days ago
- #fecal immunochemical testing
- #colonoscopy
- #colorectal cancer screening
- The SCREESCO trial compared colorectal cancer (CRC) screening methods: colonoscopy, fecal immunochemical testing (FIT), and usual care (no screening).
- Participants aged 60 were randomized to once-only colonoscopy, two rounds of FIT, or usual care in a 1:6:2 ratio.
- After a median follow-up of 4.8 years, CRC incidence rates were similar between screening and control groups.
- Early-stage CRC detection (stage I-II) was higher in both the colonoscopy and FIT arms compared to controls.
- Cardiovascular and gastrointestinal events were slightly higher in the screening groups initially but later aligned with controls.
- The study suggests a benefit in CRC detection from screening but notes initial harm from adverse events.