Impact of higher versus lower PEEP on mortality in mechanically ventilated patients with Sepsis - A multicenter, multi-cohort observational analysis - PubMed
5 hours ago
- #PEEP
- #mechanical ventilation
- #sepsis mortality
- Higher PEEP (above ARDSnet low PEEP table) is linked to significantly lower mortality in mechanically ventilated septic patients in two cohorts.
- Hemodynamic parameters (lactate, vasoactive-inotropic scores) were similar or improved with higher PEEP, and hyperspectral imaging showed no adverse microcirculatory effects.
- Due to the observational design and potential confounders, findings are hypothesis-generating and require validation in randomized trials.