The efficacy and tolerability of lacosamide adjunctive therapy in children with drug-refractory epilepsy: A nationwide Turkish cohort study - PubMed
8 hours ago
- #pediatric epilepsy
- #adjunctive therapy
- #lacosamide
- Lacosamide adjunctive therapy showed sustained long-term seizure control in children with drug-refractory epilepsy.
- The overall seizure control rates were 56.9% at 12 months and 55.6% at 24 months, with a responder rate of 20.7%.
- EEG improvement occurred in 33.8% of patients, and complete EEG recovery was achieved in 6.3%.
- Drug retention rates were 73.9% at 12 months and 67.7% at 24 months, indicating good tolerability.
- Treatment-emergent adverse events were reported in 20.7% of patients, with somnolence being the most common.