NCBP2 drives colorectal cancer growth and metastasis through LIPG-mediated lipid droplet accumulation - PubMed
5 hours ago
- #Lipid Metabolism
- #Colorectal Cancer
- #RNA-binding Proteins
- NCBP2 is identified as a potential tumorigenic gene in colorectal cancer (CRC).
- NCBP2 expression is significantly elevated in CRC tissues and correlates with tumor invasion, metastasis, and poor patient survival.
- Overexpression of NCBP2 increases CRC cell proliferation, migration, and tumor invasion in vitro and in vivo.
- NCBP2 stabilizes LIPG mRNA by binding to the m7G motif in its 5'-cap structure, increasing LIPG expression.
- NCBP2 promotes lipid droplet accumulation in CRC cells in a LIPG-dependent manner.
- The NCBP2-LIPG-lipid droplet axis is a novel mechanism underlying CRC progression and metastasis, offering a potential therapeutic target.