Mining antibody functionality via AI-guided structural landscape profiling - PubMed
5 hours ago
- #AI-guided antibody profiling
- #therapeutic antibody discovery
- #SARS-CoV-2
- AI-based method developed to link antibody sequences to their functionality using high-throughput sequencing data.
- RBD-AIM tool created for high-throughput prediction of structural antibody epitopes based on sequence.
- Analysis of native B cell repertoires post-vaccination using RBD-AIM to evaluate functional biodiversity.
- Pipeline enables rapid isolation of neutralizing antibodies effective in lethal SARS-CoV-2 infection models.
- AI-guided approach can be used for therapeutic antibody discovery and functional repertoire analysis.