Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - PubMed
7 days ago
- #human genetics
- #gut microbiome
- #genome-wide association study
- Genome-wide association analyses reveal the role of human genetic variation in gut microbiota composition.
- Study involved 16,017 adults from Swedish studies and replicated in 12,652 individuals from the Norwegian HUNT study.
- Identified variants in the OR51E1-OR51E2 locus linked to microbial richness.
- Found 15 study-wide significant genetic associations involving eight loci and 14 common bacterial species.
- Confirmed previously reported associations at LCT, ABO, and FUT2 loci.
- New loci identified include MUC12, CORO7-HMOX2, SLC5A11, FOXP1, and FUT3-FUT6.
- Links gut microbial variation to gastrointestinal functions like fatty acid sensing, bile composition, and mucosal layer composition.
- Supported by metabolomics and gene expression analyses.