A transcriptomic microglia taxonomy across mouse and human pathologies - PubMed
5 hours ago
- #neuroimmunology
- #microglia
- #transcriptomics
- Single-cell studies highlight microglial diversity in various states.
- An atlas of myeloid cell states was created using single-cell RNA sequencing of over one million CNS cells from more than 30 conditions.
- The study establishes a taxonomy of myeloid cell states with 27 superclusters and 192 clusters, conserved across diseases.
- Spatial transcriptomics was used to map immune cell states within tissues and their interactions with the local environment.
- Activation-associated microglial states depend on interferon and CSF1R signaling.
- The findings provide a spatially aware taxonomic framework for CNS immune cells in health and disease.