Klotho levels and biological age acceleration: Insights from a diverse cohort of middle-aged and elderly individuals - PubMed
6 hours ago
- #Klotho
- #Biological Age Acceleration
- #Aging
- Study examines the relationship between Klotho levels and biological age acceleration (BAA) in middle-aged and elderly individuals.
- Data from 5,654 NHANES participants (2007-2010) aged 45-85 years was analyzed.
- Serum Klotho levels were measured via ELISA, and biological age was estimated using the BioAge R package.
- Results showed an inverse association between Klotho levels and BAA, with higher Klotho linked to slower aging.
- Subgroup analyses found significant associations in women, those over 60, and individuals without chronic illnesses.
- Age, alcohol intake, and diabetes status were found to modify the Klotho-BAA relationship.
- A non-linear L-shaped dose-response pattern suggests Klotho's protective effect is more pronounced above a certain threshold.
- Findings highlight Klotho's role in aging biology and the need to consider demographic and health-related factors in future research.