Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models - PubMed
5 hours ago
- #SHANK3
- #extracellular vesicles
- #autism spectrum disorder
- Extracellular vesicles (EVs) from stem cells can rescue cellular and behavioral deficits in SHANK3-associated autism spectrum disorder (ASD) models.
- SHANK3 deficiency leads to hyperexcitability and accelerated maturation in cortical neurons, which can be transferred via EVs.
- Proteomic analysis shows enrichment of synaptic structural regulators in SHANK3 mutant neuron-derived EVs.
- EVs from mesenchymal stem cells (MSCs) and healthy donor iPSCs contain synaptic modulators that rescue hyperexcitability and normalize maturation in SHANK3 mutant neurons.
- Intranasal administration of iPSC-derived EVs in Shank3B-/- mice significantly improves ASD-like behaviors, highlighting therapeutic potential.