Achieving Intensive Blood Pressure Control in High-Risk Patients: Implementation Insights From the ESPRIT Trial - PubMed
6 hours ago
- #hypertension
- #blood pressure control
- #ESPRIT trial
- Achieving intensive BP control (<120 mm Hg systolic) is feasible in high-risk hypertensive patients with modest additional resources, as shown in the ESPRIT trial.
- Implementation challenges: Older age, male sex, higher baseline SBP, longer hypertension duration, diabetes, and more baseline medications reduce likelihood of sustained intensive control.
- Time to intensive control median was 62 days, longer with higher baseline SBP, obesity, or diabetes; medication use and clinic visits were higher in the intensive arm initially.
- No significant heterogeneity in treatment effects across most subgroups except for myocardial infarction, indicating broad applicability.
- Applying ESPRIT insights could improve global BP control and reduce cardiovascular burden.