SYNGR3 Accelerates α-Synuclein Aggregation and Neurodegeneration in Parkinson's Disease - PubMed
8 hours ago
- #α-synuclein aggregation
- #SYNGR3
- #Parkinson's disease
- SYNGR3 levels increase with age in the striatum of a Parkinson's disease mouse model (TgA53T).
- SYNGR3 directly interacts with α-synuclein, accelerating its aggregation into more stable fibrils.
- Overexpression of SYNGR3 worsens α-synuclein aggregation, synaptic loss, mitochondrial dysfunction, and cell death in cells.
- In mice, SYNGR3 intensifies α-synuclein pathology, neurodegeneration, and motor deficits.
- Knockdown of SYNGR3 alleviates these pathological and behavioral impairments, suggesting therapeutic potential.