Glial Fibrillary Acidic Protein and Neurofilament Light Reference Intervals in Healthy Individuals - PubMed
3 hours ago
- #biomarkers
- #reference intervals
- #neurology
- Study developed reference intervals (RIs) for plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) in cognitively unimpaired individuals.
- Key physiological modifiers affecting NfL and GFAP levels include older age, lower BMI, reduced kidney function (eGFR), and female sex (for GFAP).
- NfL was most elevated in frontotemporal dementia (FTD) and vascular dementia (VaD), while GFAP was highest in Alzheimer's disease dementia.
- A user-friendly interface was created to visualize RIs based on individual profiles like age, BMI, eGFR, and sex.
- Findings aim to aid clinical interpretation of plasma NfL and GFAP for neurological conditions.