A comparison of deep multiomics profiles across ethnicity, geography, and age - PubMed
3 hours ago
- #ethnicity
- #aging
- #multiomics
- Comprehensive multiomics profiling (genomics, transcriptomics, proteomics, metabolomics, lipidomics, metallomics, glycomics, microbiomics) was performed on 322 healthy individuals of European, East Asian, and South Asian ancestry across multiple continents.
- Ethnicity-associated molecular features were linked to host metabolism, autoimmune disease risk, drug metabolism, and neurodegenerative pathways.
- Ancestry and geography influenced metabolism, immune function, microbiome composition, and biological aging, with specific genetic variants and gene expression differences related to lipid metabolism and immune regulation.
- Geography affected biological age: East Asians showed lower biological age in ancestral regions, while Europeans exhibited lower biological age in the US/Canada compared to Europe.
- Ethnicity-specific patterns were observed in diet-microbiome metabolism interactions, many of which related to health.