The protein RAB5IF promotes BDNF signaling by stimulating the SUMOylation of Gαi1/3 to reduce depressive-like behaviors in mice - PubMed
6 hours ago
- #depression
- #BDNF signaling
- #SUMOylation
- RAB5IF promotes BDNF signaling by enhancing SUMOylation of Gαi1/3 to reduce depressive-like behaviors in mice.
- Chronic mild stress impairs Gαi1/3 SUMOylation, disrupting TrkB signaling complexes and downstream Akt-mTOR pathways.
- RAB5IF deficiency in hippocampal neurons leads to impaired BDNF signaling, mitochondrial dysfunction, and synaptic deficits.
- Overexpression of RAB5IF in the hippocampus mitigates depressive-like behaviors by restoring Gαi1/3 SUMOylation.
- SUMOylation at Lys277 of Gαi1/3 is essential for BDNF-induced TrkB complex formation and antidepressant effects.