Sleep chart of biological ageing clocks in middle and late life - PubMed

3 hours ago

Sleep duration shows a U-shaped relationship with biological age gaps across multiple organ systems and omics technologies.
Optimal sleep (6.4 to 7.8 hours) minimizes biological age gaps, with variations by organ and sex.
Short (<6h) and long (>8h) sleep durations are linked to increased risks of systemic diseases and all-cause mortality.
Long sleep may affect late-life depression partially through ageing clocks, while short sleep has a more direct association.
Sleep optimization could promote healthy ageing, reduce disease risk, and extend longevity, though reverse causality cannot be fully excluded.

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