LncRNA Gm16023 ameliorates hyperglycemia-exacerbated septic intestinal injury by modulating macrophage polarization via miR-377-3p/Sirt1 axis - PubMed
5 hours ago
- #Macrophage Polarization
- #Diabetic Sepsis
- #LncRNA
- Hyperglycemia is significantly associated with increased sepsis risk, as shown by data from 404,184 individuals in the UK Biobank cohort.
- Hyperglycemia enhances macrophage infiltration and exacerbates intestinal inflammation in septic patients and murine models.
- Macrophage depletion, through genetic or chemical methods, attenuates hyperglycemia-driven septic intestinal injury, highlighting their pathogenic role.
- LncRNA Gm16023 acts as a ceRNA, binding miR-377-3p to regulate Sirt1 expression and inhibit M1 macrophage polarization.
- A lipid nanoparticle (LNP)-encapsulated Gm16023 plasmid system was developed for therapeutic delivery, showing protection against intestinal injury in models.
- The study suggests the lncRNA Gm16023/miR-377-3p/Sirt1 axis as a potential RNA-based therapeutic target for diabetic sepsis.