Evolving burden and consequences of frailty in patients with acute myocardial infarction: evidence from a nationwide cohort - PubMed
6 hours ago
- #acute myocardial infarction
- #mortality
- #frailty
- Frailty is common in acute myocardial infarction (AMI) patients, with 13% having severe frailty, 22% moderate, and 36% mild frailty.
- Patients with severe frailty received less evidence-based care, including lower rates of coronary angiography (44.8% vs. 69.3%), dual antiplatelet therapy (75.5% vs. 93.4%), and cardiac rehabilitation referral (71.8% vs. 89.7%).
- Frailty showed a graded association with worse outcomes: severe frailty had a 3.01-fold higher 1-year mortality risk compared to fit patients.
- Similar dose-response patterns were observed for cardiovascular death, MACE, heart failure readmission, and major bleeding.
- Over one-third of AMI patients had moderate or severe frailty, linked to reduced care quality and poorer outcomes.