Polysaccharide-based inflammatory microenvironment-responsive nanocarriers for ulcerative colitis: Advances in design, mechanisms, and therapeutic applications - PubMed
5 hours ago
- #ulcerative-colitis
- #nanocarriers
- #drug-delivery
- Polysaccharide-based inflammatory microenvironment-responsive nanocarriers (PIMRNs) offer novel opportunities for ulcerative colitis (UC) management.
- PIMRNs exhibit bioactivity, biocompatibility, and multifunctional modulation capabilities, enabling precise targeting and controlled drug release.
- The inflammatory microenvironment of UC, including elevated reactive oxygen species, dysregulated pH, and enzyme overexpression, triggers PIMRNs for spatiotemporally controlled drug release.
- PIMRNs enhance therapeutic efficacy while minimizing off-target adverse effects, potentially transforming UC treatment paradigms.
- The review outlines recent advances in PIMRNs, design principles, optimization strategies, and challenges for clinical translation.