Plasma exchange for severe alveolar hemorrhage in ANCA-associated vasculitis: emulation of a target trial - PubMed
5 hours ago
- #ANCA-associated vasculitis
- #alveolar hemorrhage
- #plasma exchange
- Plasma exchange (PLEX) was evaluated for its effect on mortality in severe ANCA-associated vasculitis (AAV)-related diffuse alveolar hemorrhage (DAH).
- The study emulated a target trial using retrospective data from a national multicenter cohort of 184 patients with severe AAV-related DAH.
- No significant difference in 30-day mortality was found between patients who received PLEX (85% survival) and those who did not (88% survival).
- Baseline characteristics were similar except for more severe renal impairment and higher cyclophosphamide use in the PLEX group.
- The study concluded that PLEX did not reduce 30-day mortality in patients with severe AAV-related DAH.