SPOP-mediated nuclear ubiquitination degradation of p62/SQSTM1 contributes to HR repair - PubMed
5 hours ago
- #Radiotherapy
- #DNA repair
- #Ubiquitination
- SPOP interacts more strongly with p62/SQSTM1 in the nucleus after DNA damage.
- SPOP ubiquitinates p62/SQSTM1 at lysine 7, leading to its degradation and promoting HR repair by upregulating RAD51 and FLNA.
- Mutations in p62/SQSTM1's SPOP-binding motif increase radiotherapy sensitivity by impairing HR repair through reduced RAD51 and FLNA stability.