Mitochondrial matrix protein RTN4IP1 promotes the progression and metastasis of triple-negative breast cancer through metabolic reprogramming - PubMed
5 hours ago
- #Metabolic reprogramming
- #Triple-negative breast cancer
- #Mitochondrial protein
- RTN4IP1, a mitochondrial matrix protein, is linked to poorer survival in breast cancer, especially triple-negative breast cancer (TNBC).
- Knockdown of RTN4IP1 in TNBC cells reduces invasion, migration, and lung metastasis in vivo by depleting NAD+/NADH pools, impairing both oxidative phosphorylation and glycolysis.
- RTN4IP1 physically interacts with adenylate kinase 4 (AK4), which is essential for its pro-metastatic effects, suggesting the RTN4IP1-AK4 axis as a therapeutic target for TNBC metastasis.