Gut Microbiota and Metabolic Health: From Dysbiosis to Therapeutics - PubMed
5 hours ago
- #dysbiosis
- #gut-microbiota
- #metabolic-health
- The gut microbiota (GM) plays a crucial role in host metabolism and is linked to obesity, type 2 diabetes (T2D), and metabolic syndrome (MS).
- Dysbiosis, or disruptions in GM composition and function, contributes to metabolic dysfunction through pathways like enhanced energy extraction, intestinal barrier compromise, and chronic inflammation.
- Beyond bacteria, the gut virome and mycobiota also influence metabolic risk, with reduced virome diversity and altered phage-bacteria interactions worsening dysbiosis.
- Therapeutic strategies targeting GM dysbiosis include dietary changes, prebiotics, probiotics, and fecal microbiota transplantation (FMT), though results vary in human trials.
- Established metabolic treatments like GLP-1 receptor agonists and bariatric surgery also reshape the GM.
- Future metabolic management may involve personalized microbiomics, using AI and precision interventions to address individual microbial deficits.